I’ve been trying to upload this paper on Paperpile and the pdf is unusually large (~160MB). I find that the pdf is not uploaded to google drive when uploading through paperpile and I can’t access the pdf in another computer than the one I uploaded it on. However, it works fine if I directly upload it to google drive. In addition, I found that even when uploaded on the same computer, when I try to open it, it opens as a ViewOnly pdf and I cannot add any annotations. This made me wonder if there is a size limit to uploads or was it limited to the pdf that I was trying to add to my library. Other papers work fine (but are really much smaller in size).
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Yes there is, but I can’t find the reference in the documentation. As far as I remember the limit is 3MB.
Not 100 MB?
According to the troubleshooting guide the limit is 100 MB.
Very large PDFs are almost invariably unnecessarily so. The most common culprit I have seen is when high-resolution images from scientific equipment - much larger than what is necessary - are included in the PDF. I suggest compressing the PDF before uploading it, this will also make it easier for the PDF annotator to work with the file. There are several online services that will compress a PDF for free.
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Ya, I thought the journal would have compressed the images to some extent before adding it to their website. 160MB is a tad too large. It works when compressed - I was just curious to see what the limit was. Thanks for the link @Jason_Jensen.
My largest is ~90MB and still opens (slowly) in the annotated pdf viewer, so that’s one data point 
And trust me, I’ve compressed mine as much as possible, but they are scans of art books. I split one book into two parts just to keep the size down.